HISTOPATHOLOGICAL AND HAEMATOLOGICAL EFFECTS OF AQUEOUS EXTRACT CNIDOSCOLUS ACONTIFOLIUS ON THE LIVER AND KIDNEY IN ADULT WISTAR RAT

²Ebeye O.A, ¹Ekundina V.O and ²Mokwe M

¹Department of Medical Laboratory Science, Afe-Babalola University, Ado-Ekiti, Ekiti State

²Department of Human Anatomy and Cell BiologyDelta State University, Abraka.

email:Kemvic30@gmail.com

ABSTRACT

The effects of chronic administration of aqueous leaf extract of cnidoscolus aconitifolius on some heamatological and histopathological parameters of the kidney and liver of wistar rats.  Twenty four (24) adult wistar rats were acclimatized, weighed and sorted into four groups (A-D) of 6 animals each with corresponding body weights in the same group. Aqueous leaf extracts of cnidoscolus aconitifolius was administered orally to rats in groups B-D at 200mg/kg, 400mg/kg and 600mg/kg body weight respectively for 28 days aside the normal feed and water while group A which served as the control was given only feed and water for the same duration. At the end of administration, animals were sacrificed and blood was collected from the inferior venecava into vials containing EDTA for the various tests while the kidney and liver samples were quickly fixed in 10% formol saline. Tissue sections of the samples were processed and stained using hematoxylin and eosin stains respectively. Results showed increase in WBC (leukocytosis), glomerular degeneration as seen in proliferative glomerulopathy as well as hepatic damage evident in periportal fibrosis at the highest dose (600mg/kg). Consumption of cnidocolus acontifolius should be with caution as it elicited a dose  dependent damaging effects on the organ studied.