EFFECT OF AQUEOUS LEAF EXTRACT OF Murraya Koenigii ON SOME BIOCHEMICAL AND HAEMATOLOGICAL INDICES OF NORMAL AND ALLOXAN-INDUCED DIABETIC RATS

Joel Enoch B., Lenka Jessica L, and Luka Carrol D.

Department of Biochemistry, University of Jos, Nigeria

Email: enjoebest@yahoo.com

ABSTRACT

The effect of aqueous leaf extract of murraya koenigii on glycemic and some biochemical and haematological indices of normal and alloxan-induced diabetic rats was evaluated. Twenty albino rats were randomized into four groups (A-D), such that group A (non-diabetic) received 0.5 ml distilled water, group B (diabetic untreated) received 0.5 ml distilled water, group C (diabetic treated) received 200 mg/kg bwt of extract while group D (control treated) received 200 mg/kg bwt of extract. The blood glucose of alloxanized rats significantly and progressively reduced in extract treated animals. The significant (p<0.05) increase in the levels of the creatinine, protein and urea in the untreated diabetic rats was reduced significantly in the diabetic treated rats with the protein and urea values below the control group. The significant (p<0.05) decrease in the levels of Packed Cell Volume (PCV), Haemoglobin (Hb), Red Blood Cells (RBC) and White blood cells (WBC) of diabetic untreated rats were significantly (p<0.05) elevated in diabetic treated rats. With the exception of ALP, the elevations in the activities of ALT and AST were reverted back to their respective control in the extract treated animals. The significant (p<0.05) increase in the levels of total cholesterol and triacylglycerol observed in the diabetic animals was drastically decreased to near normal level after administration of extract. The results obtained indicated that oral administration of aqueous leaf extract of Murraya koenigii at the dosage and duration used resulted in hypoglycemia as well as reversal of the adverse complications associated with diabetics.