Dose Concentration of Ethanolic Extract of Garcinia Kola Seed Impairs Reproductive Function in Adult Male Albino Wistar Rats
1Agbai E.O., 2Ofoego U.C., 1Nwanegwo C.O., and 2Nwodo F.N.
1Department of Human Physiology
2Department of Human Anatomy
University Elele, Rivers State, Nigeria.
ABSTRACT
This present study investigate the effect of Garcinia kola on testicular weight, serum testosterone, luteinizing hormone and sperm count in adult male albino wistar rats after
administration of ethanolic extract of Garcinia kola seeds at different dose concentration Twenty-five adult male albino wistar rats were randomly assigned into four groups (A, B,
C and D). Group A served as the control group and were fed with normal rat chow. Group B received oral administration of extract (100 mg/kg body weight). Group C and
Group D received oral administration of extract (200 mg/kg and 300 mg/kg body weight) respectively. Administration of extract lasted for six weeks after which they were
sacrificed. Statistically significant difference at P < 0.05 in the weight of epididymis was recorded between Group A (0.64 ± 0.02) compared to Group C (1.13 ± 0.07). There
was also statistically significance at P < 0.05 between Group A (0.64 ± 0.02) compared to Group D (1.46 ± 0.12). The weight of the testes showed statistically significant difference at P < 0.05 between Group A (1.53 ± 0.16) compared to Group B (1.35 ±
0.09). There was statistically significant difference at P < 0.05 between Group A (1.53 ± 0.16) and Group C (1.31 ± 0.05). There was also statistically significant decrease at P <
0.05 between Group A (1.53 ± 0.16) and Group D (0.74 ± 0.1). Statistically significant difference in the serum LH level was recorded at P < 0.05 between Group A (4.21 ±
0.04) compared to Group C (4.41 ± 0.37). There was also statistically significance at P< 0.05 between Group A (4.21 ± 0.04) compared to Group D (4.51 ± 0.04).Testosterone level was statistically significant difference at P < 0.05 between Group A
(1.34 ± 0.14) compared to Group C (12.1 ± 0.03). There was also statistically significant