DYSLIPIDAEMIA IN NON INSULIN DEPENDENT DIABETES MELLITUS

J.O. Alegbejo

Department of Paediatrics

Ahamadu Bello University Teaching Hospital, Shika, Zaria, Nigeria

ABSTRACT

Lipid is one of the identifiable deranged disorder in type – 2 diabetics, therefore the study was conducted to measure the serum lipids in type-2 diabetics subjects attending clinic in ABUTH, Shika, Zaria, Nigeria.  Thirty – three type – 2 diabetic subjects and 13 healthy subjects participated in the study. Serum concentrations of total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), Triacylglycerol (TG), very low-density lipoprotein (VLDL-C) cholesterol and TC/HDL-C ratio (atherogenic index) were measured. The total cholesterol means in both type 2 diabetics (2.83±0.81) and control (3.21±0.75) were within normal limits. In the type 2 diabetic subjects, the mean value of Triacylglycerol TG was 3.91±3.54 while the control subjects value was 1.83±1.05 (p<0.05) and also was higher than the normal range. The mean HDL-Cholesterol was 0.81±0.92mmol/L in diabetic subjects while it was 0.56±0.27 (p>0.5) in control subjects and both were within normal range. The LDL was significantly higher in the diabetic group than the control subjects although both were within normal range. The atherogenic index was significantly higher in the apparently healthy subjects than the diabetics’ subjects. This study therefore emphasizes that in this condition, lipid profile analysis is still essential and the effective management of lipid abnormalities is required when diabetes is diagnosed to improve and reduce the morbidity and mortality associated with lipid derangements.

Key words: Type- 2 diabetes, serum lipid, total cholesterol, low density lipoprotein cholesterol, Triacylglycerol, very low-density lipoprotein cholesterol and atherogenic index