EFFECT OF AQUEOUS EXTRACT OF MORINGA OLEIFERA SEED ON SOME BIOCHEMICAL PARAMETERS IN ALLOXAN-INDUCED DIABETIC RATS

¹Luka, C.D. and ²Rafiu, A. A

¹ Department of Biochemistry, Faculty of Medical Sciences, University of Jos, Plateau State, Nigeria

² Foods Limited, 42, Yakubu Gowon Way, Jos, Plateau State, Nigeria.

E-mail: carrll42@yahoo.com 

ABSTRACT

The objective of this research work is to investigate some biochemical parameters in the serum of normal and alloxan-induced diabetic rats treated with Moringa oleifera seeds aqueous extract. Alloxan-induced diabetic rats (150mg/kg) were administered orally with Moringa oleifera seed aqueous extract (200 mg/kg) for twenty eight days after which some biochemical parameters in the serum was measured and compared with the control. The results showed that the level of urea, creatinine, uric acid, PO₄^3-, enzymes markers (ALT, AST, ALP) of the diabetic group were significantly (p<0.05) high when compared with the control and extract treated groups while significant (p<0.05) reduction were observed in the serum level of Ca2+ and Mg2+ of the diabetic untreated group when compared to both extract treated and control group. The administration of aqueous seed extract of Moringa oleifera to the diabetic rats showed significant (P<0.05) reduction in the level of urea, creatinine, uric acid, PO43-, enzymes markers (ALT, AST, ALP) and a significant (P<0.05) increase in the level of Ca2+ and Mg2+. Therefore, It can be concluded that administration of aqueous seed extract of Moringa oleifera to diabetic rats ameliorate the adverse effects of diabetes complications.