DETERMINATION OF ANTI-Salmonella typhi ACTIVITY OF THE CRUDE EXTRACT OF Allium sativum (GARLIC)

Yabaya A¹. Orukotan A². and Jonathan M¹.

¹Department of Microbiology, Kaduna State University, Kaduna,Nigeria

² Department of Applied Sciences, Kaduna Polytechnic, Kaduna, Nigeria

ABSTRACT

Garlic has been considered to be an excellent medical panacea and a natural antimicrobial drug that can be considered as an alternative form of treatment of pathogenic infections.The antimicrobial effects of fresh aqueous garlic extract (FAGE) and dried aqueous garlic extract (DAGE) against Salmonella typhi was studied. Antibacterial activity of FAGE and DAGE was characterised by inhibition zones of 5-29 mm and 5-19 mm respectively with FAGE giving a higher sensitivity against the tested isolate. Salmonella typhi was tested against some commercial antibiotics, susceptibility of  S. typhi to these antibiotics was characterised by inhibition zones of 10-26mm against four antibiotics and no sensitivity or inhibition zones were recorded for six antibiotics. The partition principle of paper and TLC reveals that FAGE had more component ingredients than DAGE. The observations made in this study supports the use of garlic in health products and herbal remedies as a low cost intervention in the enhanced therapy against bacterial infections in Nigeria.

Keywords: Antibacterial Effect, Allium sativum,Anti -Salmonella typhi.